Cervical cancer is the most common gynecologic malignancy and leading cause of death in Korean women. Although the precise etiology of cervical cancer is unknown, epidemiologic studies suggest that venereally transmitted infectious agents could
play an
important role in the etiology of cervical cancer. Recently, human papillomavirus(HPV) has been reported to be associated with neoplastic change.
A very sensitive polymerase chain reaction(PCR) capable of amplifying specific DNA sequence by up to a millionfold was developed for detection of HPV DNA.
The purpose of this study is to investigate the efficacy of cervical cytology and PCR for detection of HPV type 16, 18 and to study the possible role of PCR as complementary test for identification of high-risk group which can not be detected by
cervical cytology alone.
This study included 102 cases, 85 cases showing normal cytology and 17 cases showing abnormal cytology.
@ES The results were as follows;
@EN 1. Positive rates of HPV type 16 and 18 were 11.8% and 1.2%, respectively, among 85cases showing normal cytology.
2. Positive rates of HPV type 16 and 18 were 41.2% and 23.5%, respectively, among 17 cases showing abnormal cytology. Especially, overall positive rate of HPV type 16 and/or type 18 was 83.3% among 6 cases diagnosed as invasive cervical cancer.
According to these results, concurrent use of HPV detection by PCR from cervical scrapes with cytologic examination seems to be a complementary method for prevention of cervical cancer.
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